Somatostatin induces rapid contraction of neuroendocrine cells

• The peptide hormone somatostatin, as well as the somatostatin analog octreotide, induces rapid morphological changes in neuroendocrine cells. The effect can be detected in less than 2min: retraction fibers are formed, cells round up and cell–cell contacts are broken. Somatostatin-dependent cell contraction is inhibited by Y-27632, indicating that this effect is dependent on Rho kinase. In BON1 cells, the somatostatin-induced inhibition of forskolin-induced secretion of chromogranin A is not blocked by Y-27632. It is therefore concluded that the inhibitory effect of somatostatin in forskolin-stimulated cells is not dependent on cell contraction.

Keyword

Actin cytoskeleton

Cell contraction

Rho kinase

Secretion

Somatostatin

MEDICINE

MEDICIN

Publication and Content Type

ref (subject category)

art (subject category)